Synergistic clearance of intracellular pathogens by hyaluronan-streptomycin micelles encapsulated with rapamycin.
Identifieur interne : 000223 ( Main/Exploration ); précédent : 000222; suivant : 000224Synergistic clearance of intracellular pathogens by hyaluronan-streptomycin micelles encapsulated with rapamycin.
Auteurs : Yuanhao Qiu [République populaire de Chine] ; Chunbo Lu [République populaire de Chine] ; Peng Chen [République populaire de Chine] ; Feifei Sun [République populaire de Chine] ; Dongdong Wang [République populaire de Chine] ; Zhaojie Wang [République populaire de Chine] ; Chunyan Hou [République populaire de Chine] ; Haibo Mu [République populaire de Chine] ; Jinyou Duan [République populaire de Chine]Source :
- Carbohydrate polymers [ 1879-1344 ] ; 2019.
Descripteurs français
- KwdFr :
- Acide hyaluronique (composition chimique), Animaux (MeSH), Autophagie (effets des médicaments et des substances chimiques), Capsules (MeSH), Cellules RAW 264.7 (MeSH), Espace intracellulaire (effets des médicaments et des substances chimiques), Espace intracellulaire (microbiologie), Interactions hydrophobes et hydrophiles (MeSH), Libération de médicament (MeSH), Micelles (MeSH), Salmonella typhimurium (effets des médicaments et des substances chimiques), Salmonella typhimurium (physiologie), Sirolimus (composition chimique), Sirolimus (pharmacologie), Souris (MeSH), Streptomycine (composition chimique), Streptomycine (pharmacologie), Synergie des médicaments (MeSH), Vecteurs de médicaments (composition chimique), Viabilité microbienne (effets des médicaments et des substances chimiques).
- MESH :
- composition chimique : Acide hyaluronique, Sirolimus, Streptomycine, Vecteurs de médicaments.
- effets des médicaments et des substances chimiques : Autophagie, Espace intracellulaire, Salmonella typhimurium, Viabilité microbienne.
- microbiologie : Espace intracellulaire.
- pharmacologie : Sirolimus, Streptomycine.
- physiologie : Salmonella typhimurium.
- Animaux, Capsules, Cellules RAW 264.7, Interactions hydrophobes et hydrophiles, Libération de médicament, Micelles, Souris, Synergie des médicaments.
English descriptors
- KwdEn :
- Animals (MeSH), Autophagy (drug effects), Capsules (MeSH), Drug Carriers (chemistry), Drug Liberation (MeSH), Drug Synergism (MeSH), Hyaluronic Acid (chemistry), Hydrophobic and Hydrophilic Interactions (MeSH), Intracellular Space (drug effects), Intracellular Space (microbiology), Mice (MeSH), Micelles (MeSH), Microbial Viability (drug effects), RAW 264.7 Cells (MeSH), Salmonella typhimurium (drug effects), Salmonella typhimurium (physiology), Sirolimus (chemistry), Sirolimus (pharmacology), Streptomycin (chemistry), Streptomycin (pharmacology).
- MESH :
- chemical , chemistry : Drug Carriers, Hyaluronic Acid, Sirolimus, Streptomycin.
- chemical , pharmacology : Sirolimus, Streptomycin.
- chemical : Capsules, Micelles.
- drug effects : Autophagy, Intracellular Space, Microbial Viability, Salmonella typhimurium.
- microbiology : Intracellular Space.
- physiology : Salmonella typhimurium.
- Animals, Drug Liberation, Drug Synergism, Hydrophobic and Hydrophilic Interactions, Mice, RAW 264.7 Cells.
Abstract
Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize inside, which protects them from the attack by host immune system and antibiotics. A novel amphiphilic molecule was synthesized through conjugation of streptomycin and decylamine to hyaluronan. Rapamycin was encapsulted by the spontaneous self-assembly of hyaluronan-based amphiphilic molecules. The newly formed micelles not only facilitated the entry of drugs into host cells in part via CD44 phagocytic receptor, released streptomycin in the acidic compartment, but also could activate autophagy. The micelles elicited an efficient killing capacity against intracellular bacteria through the promotion of streptomycin uptake and rapamycin-initiated activation of autophagy. This strategy might highlight an acid-sensitive hyaluronan-based drug delivery system for effective treatment of intracellular infections.
DOI: 10.1016/j.carbpol.2019.01.068
PubMed: 30732772
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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College of Medicine, Pingdingshan University, Pingdingshan, Henan, 467000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China; College of Medicine, Pingdingshan University, Pingdingshan, Henan, 467000</wicri:regionArea><wicri:noRegion>467000</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Chunbo" sort="Lu, Chunbo" uniqKey="Lu C" first="Chunbo" last="Lu">Chunbo Lu</name><affiliation wicri:level="1"><nlm:affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Peng" sort="Chen, Peng" uniqKey="Chen P" first="Peng" last="Chen">Peng Chen</name><affiliation wicri:level="1"><nlm:affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Feifei" sort="Sun, Feifei" uniqKey="Sun F" first="Feifei" last="Sun">Feifei Sun</name><affiliation wicri:level="1"><nlm:affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Dongdong" sort="Wang, Dongdong" uniqKey="Wang D" first="Dongdong" last="Wang">Dongdong Wang</name><affiliation wicri:level="1"><nlm:affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Zhaojie" sort="Wang, Zhaojie" uniqKey="Wang Z" first="Zhaojie" last="Wang">Zhaojie Wang</name><affiliation wicri:level="1"><nlm:affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Hou, Chunyan" sort="Hou, Chunyan" uniqKey="Hou C" first="Chunyan" last="Hou">Chunyan Hou</name><affiliation wicri:level="1"><nlm:affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Mu, Haibo" sort="Mu, Haibo" uniqKey="Mu H" first="Haibo" last="Mu">Haibo Mu</name><affiliation wicri:level="1"><nlm:affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address: mhb1025@nwafu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Duan, Jinyou" sort="Duan, Jinyou" uniqKey="Duan J" first="Jinyou" last="Duan">Jinyou Duan</name><affiliation wicri:level="1"><nlm:affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address: jduan@nwsuaf.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author></analytic><series><title level="j">Carbohydrate polymers</title><idno type="eISSN">1879-1344</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Autophagy (drug effects)</term><term>Capsules (MeSH)</term><term>Drug Carriers (chemistry)</term><term>Drug Liberation (MeSH)</term><term>Drug Synergism (MeSH)</term><term>Hyaluronic Acid (chemistry)</term><term>Hydrophobic and Hydrophilic Interactions (MeSH)</term><term>Intracellular Space (drug effects)</term><term>Intracellular Space (microbiology)</term><term>Mice (MeSH)</term><term>Micelles (MeSH)</term><term>Microbial Viability (drug effects)</term><term>RAW 264.7 Cells (MeSH)</term><term>Salmonella typhimurium (drug effects)</term><term>Salmonella typhimurium (physiology)</term><term>Sirolimus (chemistry)</term><term>Sirolimus (pharmacology)</term><term>Streptomycin (chemistry)</term><term>Streptomycin (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide hyaluronique (composition chimique)</term><term>Animaux (MeSH)</term><term>Autophagie (effets des médicaments et des substances chimiques)</term><term>Capsules (MeSH)</term><term>Cellules RAW 264.7 (MeSH)</term><term>Espace intracellulaire (effets des médicaments et des substances chimiques)</term><term>Espace intracellulaire (microbiologie)</term><term>Interactions hydrophobes et hydrophiles (MeSH)</term><term>Libération de médicament (MeSH)</term><term>Micelles (MeSH)</term><term>Salmonella typhimurium (effets des médicaments et des substances chimiques)</term><term>Salmonella typhimurium (physiologie)</term><term>Sirolimus (composition chimique)</term><term>Sirolimus (pharmacologie)</term><term>Souris (MeSH)</term><term>Streptomycine (composition chimique)</term><term>Streptomycine (pharmacologie)</term><term>Synergie des médicaments (MeSH)</term><term>Vecteurs de médicaments (composition chimique)</term><term>Viabilité microbienne (effets des médicaments et des substances chimiques)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Drug Carriers</term><term>Hyaluronic Acid</term><term>Sirolimus</term><term>Streptomycin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Sirolimus</term><term>Streptomycin</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Capsules</term><term>Micelles</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Acide hyaluronique</term><term>Sirolimus</term><term>Streptomycine</term><term>Vecteurs de médicaments</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term><term>Intracellular Space</term><term>Microbial Viability</term><term>Salmonella typhimurium</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Autophagie</term><term>Espace intracellulaire</term><term>Salmonella typhimurium</term><term>Viabilité microbienne</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Espace intracellulaire</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Intracellular Space</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Sirolimus</term><term>Streptomycine</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Salmonella typhimurium</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Salmonella typhimurium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Liberation</term><term>Drug Synergism</term><term>Hydrophobic and Hydrophilic Interactions</term><term>Mice</term><term>RAW 264.7 Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Capsules</term><term>Cellules RAW 264.7</term><term>Interactions hydrophobes et hydrophiles</term><term>Libération de médicament</term><term>Micelles</term><term>Souris</term><term>Synergie des médicaments</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize inside, which protects them from the attack by host immune system and antibiotics. A novel amphiphilic molecule was synthesized through conjugation of streptomycin and decylamine to hyaluronan. Rapamycin was encapsulted by the spontaneous self-assembly of hyaluronan-based amphiphilic molecules. The newly formed micelles not only facilitated the entry of drugs into host cells in part via CD44 phagocytic receptor, released streptomycin in the acidic compartment, but also could activate autophagy. The micelles elicited an efficient killing capacity against intracellular bacteria through the promotion of streptomycin uptake and rapamycin-initiated activation of autophagy. This strategy might highlight an acid-sensitive hyaluronan-based drug delivery system for effective treatment of intracellular infections.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30732772</PMID><DateCompleted><Year>2019</Year><Month>05</Month><Day>20</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1344</ISSN><JournalIssue CitedMedium="Internet"><Volume>210</Volume><PubDate><Year>2019</Year><Month>Apr</Month><Day>15</Day></PubDate></JournalIssue><Title>Carbohydrate polymers</Title><ISOAbbreviation>Carbohydr Polym</ISOAbbreviation></Journal><ArticleTitle>Synergistic clearance of intracellular pathogens by hyaluronan-streptomycin micelles encapsulated with rapamycin.</ArticleTitle><Pagination><MedlinePgn>364-371</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0144-8617(19)30084-0</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.carbpol.2019.01.068</ELocationID><Abstract><AbstractText>Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize inside, which protects them from the attack by host immune system and antibiotics. A novel amphiphilic molecule was synthesized through conjugation of streptomycin and decylamine to hyaluronan. Rapamycin was encapsulted by the spontaneous self-assembly of hyaluronan-based amphiphilic molecules. The newly formed micelles not only facilitated the entry of drugs into host cells in part via CD44 phagocytic receptor, released streptomycin in the acidic compartment, but also could activate autophagy. The micelles elicited an efficient killing capacity against intracellular bacteria through the promotion of streptomycin uptake and rapamycin-initiated activation of autophagy. This strategy might highlight an acid-sensitive hyaluronan-based drug delivery system for effective treatment of intracellular infections.</AbstractText><CopyrightInformation>Copyright © 2019. Published by Elsevier Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Qiu</LastName><ForeName>Yuanhao</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China; College of Medicine, Pingdingshan University, Pingdingshan, Henan, 467000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Chunbo</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Peng</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Feifei</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Dongdong</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Zhaojie</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hou</LastName><ForeName>Chunyan</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mu</LastName><ForeName>Haibo</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address: mhb1025@nwafu.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duan</LastName><ForeName>Jinyou</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address: jduan@nwsuaf.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>01</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Carbohydr Polym</MedlineTA><NlmUniqueID>8307156</NlmUniqueID><ISSNLinking>0144-8617</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002214">Capsules</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004337">Drug Carriers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008823">Micelles</NameOfSubstance></Chemical><Chemical><RegistryNumber>9004-61-9</RegistryNumber><NameOfSubstance UI="D006820">Hyaluronic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical><Chemical><RegistryNumber>Y45QSO73OB</RegistryNumber><NameOfSubstance UI="D013307">Streptomycin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002214" MajorTopicYN="N">Capsules</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004337" MajorTopicYN="N">Drug Carriers</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D065546" MajorTopicYN="N">Drug Liberation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004357" MajorTopicYN="N">Drug Synergism</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006820" MajorTopicYN="N">Hyaluronic Acid</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057927" MajorTopicYN="N">Hydrophobic and Hydrophilic Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042541" MajorTopicYN="N">Intracellular Space</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008823" MajorTopicYN="Y">Micelles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050296" MajorTopicYN="N">Microbial Viability</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000067996" MajorTopicYN="N">RAW 264.7 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012486" MajorTopicYN="N">Salmonella typhimurium</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013307" MajorTopicYN="N">Streptomycin</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Aminoglycosides</Keyword><Keyword MajorTopicYN="N">Autophagy</Keyword><Keyword MajorTopicYN="N">Hyaluronic acid</Keyword><Keyword MajorTopicYN="N">Intracellular bacteria</Keyword><Keyword MajorTopicYN="N">Micelles</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>09</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>01</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>01</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>2</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>2</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>5</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30732772</ArticleId><ArticleId IdType="pii">S0144-8617(19)30084-0</ArticleId><ArticleId IdType="doi">10.1016/j.carbpol.2019.01.068</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Qiu, Yuanhao" sort="Qiu, Yuanhao" uniqKey="Qiu Y" first="Yuanhao" last="Qiu">Yuanhao Qiu</name></noRegion><name sortKey="Chen, Peng" sort="Chen, Peng" uniqKey="Chen P" first="Peng" last="Chen">Peng Chen</name><name sortKey="Duan, Jinyou" sort="Duan, Jinyou" uniqKey="Duan J" first="Jinyou" last="Duan">Jinyou Duan</name><name sortKey="Hou, Chunyan" sort="Hou, Chunyan" uniqKey="Hou C" first="Chunyan" last="Hou">Chunyan Hou</name><name sortKey="Lu, Chunbo" sort="Lu, Chunbo" uniqKey="Lu C" first="Chunbo" last="Lu">Chunbo Lu</name><name sortKey="Mu, Haibo" sort="Mu, Haibo" uniqKey="Mu H" first="Haibo" last="Mu">Haibo Mu</name><name sortKey="Sun, Feifei" sort="Sun, Feifei" uniqKey="Sun F" first="Feifei" last="Sun">Feifei Sun</name><name sortKey="Wang, Dongdong" sort="Wang, Dongdong" uniqKey="Wang D" first="Dongdong" last="Wang">Dongdong Wang</name><name sortKey="Wang, Zhaojie" sort="Wang, Zhaojie" uniqKey="Wang Z" first="Zhaojie" last="Wang">Zhaojie Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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